Azarenka Belarusian tennis player, tournament champion Miami last week, was winning by a score of 5-1 while Safina, the ranking has slipped to rank 81, decided to withdraw from the match in Marbella it.
"It's not nice to win like this, especially from opponents such as Dinara, "said Azarenka at a news conference, reports Reuters.
"He had long been struggling with injury, and I hope he can recover soon," said Azarenka.
Next Azarenka will face Sara Errani in the semi-finals to be held on Saturday (Sunday GMT) after the eighth seed from the Italian, who beat fourth seed Alexandra Dulgheru of Romania 6-2 6-2.
Remaining matches on this Friday is the quarter-final match between second seed Svetlana Kuznetsova of Russia beat qualifier against Spain's Lara Arruabarrena-Vecino, and the game sixth-seeded Klara Zakopalova of the Czech Republic beat qualifier against Romanian Irina-Camelia Begu.